Diagnostic Molecular Pathology. A Practical Approach

A Practical Diagnostic Approach to Food Allergies

Any abnormal reaction resulting from the ingestion of a food could be considered an adverse food reaction, and not necessarily a food allergy. In the evaluation of a patient with a history of an adverse reaction to food, one must consider the broad differential diagnosis before labelling the patient as ‘allergic’ to a foodstuff. The classification of adverse reactions to food is discussed, and ...

CNS lymphoma: a practical diagnostic approach.

The concept and understanding of central nervous system (CNS) lymphoma have greatly evolved in the past few years. Better characterization of a number of lymphoproliferative neoplasms through clinical, immunophenotyping, and molecular studies is reflected in a much more complex WHO Classification of Tumours of Hematopoietic and Lymphoid Tissue. The term "primary CNS lymphoma" is now restricted ...

Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints.

This article reviews the main molecular alterations involved in endometrial carcinoma. Five molecular features (microsatellite instability, and mutations in the PTEN, k-RAS, PIK3CA and beta-catenin genes) are characteristic of endometrioid carcinomas, whereas non-endometrioid carcinomas show alterations of p53, loss of heterozygosity (LOH) on several chromosomes, as well as other molecular alte...

Current practical applications of diagnostic immunohistochemistry in breast pathology.

In recent years, immunohistochemistry has assumed an increasingly prominent role in diagnostic breast pathology. Immunohistochemistry is now frequently used in the evaluation of many epithelial proliferations of the breast. Common applications include the use of myoepithelial markers to evaluate for stromal invasion, E-cadherin to distinguish between ductal and lobular neoplasia, high molecular...

Practical Pathology